Carisoprodol (trade names embody Soma, Somadril, Carisoma, Carisoprodol Watson, Listaflex, Somacid, Vanadom) is a muscle relaxant from carbamic acid esters pharmacological group. This medicine is indicated together with rest and physical therapy to alleviate musculoskeletal ache, skeletal muscle spasms, stiffness, muscle injuries, strain, sprain, acute back pain, discomfort related to short-term, painful musculoskeletal conditions, and for other medical functions. It can also be widely off-label used as recreational drug. Carisoprodol may be prescribed alone for monotherapy or in combos with other drugs, corresponding to psycholeptics.

Clinical presentation </h2

Overdosage of Carisoprodol (Soma) tablets commonly produces CNS despair. Death, coma, respiratory depression, hypotension, seizures, delirium, hallucinations, dystonic reactions, nystagmus, blurred imaginative and prescient, mydriasis, euphoria, muscular incoordination, rigidity, and/or headache have been reported with Soma overdosage. Serotonin syndrome has been reported with carisoprodol intoxication. Many of the carisoprodol overdoses have occurred in the setting of multiple drug overdoses (including medicine of abuse, illegal medicine, and alcohol). The results of an overdose of this medication and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive even when one of the medication has been taken in the beneficial dosage. Fatal accidental and non-accidental overdoses of SOMA have been reported alone or together with CNS depressants.

Treatment of overdosage

Basic life help measures must be instituted as dictated by the scientific presentation of the Soma overdose. Vomiting should not be induced due to the risk of CNS and respiratory depression, and subsequent aspiration. Circulatory assist ought to be administered with quantity infusion and vasopressor agents if needed. Seizures must be treated with intravenous benzodiazepines and the reoccurrence of seizures may be handled with phenobarbital. In circumstances of severe CNS despair, airway protective reflexes may be compromised and tracheal intubation ought to be considered for airway safety and respiratory assist.

For decontamination in cases of extreme toxicity, activated charcoal should be considered in a hospital setting in sufferers with massive overdoses who current early and aren’t demonstrating CNS melancholy and might protect their airway.